(19)

(11)

EP 4 580 628 A1

(12)

(43) Date of publication: 09.07.2025 Bulletin 2025/28 (21) Application number: 23777406.2 (22) Date of filing: 31.08.2023

(51) International Patent Classification (IPC):  A61K 31/4439(2006.01) A61P 35/00(2006.01) A61K 31/502(2006.01) (52) Cooperative Patent Classification (CPC): A61K 31/502; A61K 31/4439; A61P 35/00 (86) International application number: PCT/US2023/031608 (87) International publication number: WO 2024/049948 (07.03.2024 Gazette 2024/10)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA Designated Validation States: KH MA MD TN (30) Priority: 01.09.2022 US 202263403201 P 19.04.2023 US 202363497022 P (71) Applicant: Mirati Therapeutics, Inc. Princeton, New Jersey 08543 (US)	(72) Inventors: ENGSTROM, Lars, Daniel Carlsbad, CA 92009 (US) OLSON, Peter San Diego, CA 92122 (US) WATERS, Laura San Diego, CA 92129 (US) BOWCUT, Vickie San Francisco, CA 94122 (US) (74) Representative: Mewburn Ellis LLP  Aurora Building Counterslip Bristol BS1 6BX Bristol BS1 6BX (GB)