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EP 4 580 631 A1

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(43) Date of publication: 09.07.2025 Bulletin 2025/28 (21) Application number: 23776753.8 (22) Date of filing: 30.08.2023

(51) International Patent Classification (IPC):  A61K 31/496(2006.01) A61K 31/519(2006.01) A61P 35/04(2006.01) A61K 31/506(2006.01) A61P 35/00(2006.01) (52) Cooperative Patent Classification (CPC): A61K 31/496; A61K 31/506; A61K 31/519; A61P 35/00; A61P 35/04   C-Sets: A61K 31/496, A61K 2300/00; A61K 31/506, A61K 2300/00; A61K 31/519, A61K 2300/00; (86) International application number: PCT/US2023/031574 (87) International publication number: WO 2024/049926 (07.03.2024 Gazette 2024/10)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA Designated Validation States: KH MA MD TN (30) Priority: 31.08.2022 US 202263402651 P 07.02.2023 US 202363443892 P 24.03.2023 US 202363454422 P 24.03.2023 US 202363454485 P 15.06.2023 US 202363508503 P (71) Applicants: Arvinas Operations, Inc. New Haven, CT 06511 (US) Pfizer Inc. New York, NY 10001-2192 (US)

(72) Inventors: PECK, Ronald Cheshire, Connecticut 06410 (US) GOUGH, Sheryl Maxine Stratford, Connecticut 06614 (US) FLANAGAN, John J. Guilford, Connecticut 06437 (US) ANDERSON, Sibyl New York, New York 10039 (US) TAYLOR, Ian Charles Anthony Madison, Connecticut 06443 (US) SMITH, Julia Perkins New York, New York 10001-2192 (US) TAN, Weiwei San Diego, California 92121 (US) (74) Representative: Müller, Christian Stefan Gerd  ZSP Patentanwälte PartG mbB Hansastraße 32 80686 München 80686 München (DE)