(19)

(11)

EP 4 580 633 A2

(12)

(88) Date of publication A3: 11.04.2024 (43) Date of publication: 09.07.2025 Bulletin 2025/28 (21) Application number: 23861487.9 (22) Date of filing: 29.08.2023

(51) International Patent Classification (IPC):  A61K 31/496(2006.01) A61K 9/127(2025.01) A61K 31/13(2006.01) A61K 48/00(2006.01) (52) Cooperative Patent Classification (CPC): C07D 295/125; A61K 47/6929; A61K 9/5123; C07K 14/705; C07K 14/7051; C07K 14/4748; C12N 9/22; C12N 2310/20; C12N 2320/32; C12N 15/111; A61K 47/541 (86) International application number: PCT/US2023/073072 (87) International publication number: WO 2024/050352 (07.03.2024 Gazette 2024/10)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA Designated Validation States: KH MA MD TN (30) Priority: 29.08.2022 US 202263373793 P (71) Applicant: The Trustees of The University of Pennsylvania Philadelphia, PA 19104 (US)	(72) Inventors: MITCHELL, Michael J. Philadelphia, Pennsylvania 19103 (US) PADILLA, Marshall Scott Philadelphia, Pennsylvania 19104 (US) (74) Representative: Evans, Sophie Elizabeth  Kilburn & Strode LLP Lacon London 84 Theobalds Road London WC1X 8NL London WC1X 8NL (GB)