(19)

(11)

EP 4 580 641 A2

(12)

(88) Date of publication A3: 18.04.2024 (43) Date of publication: 09.07.2025 Bulletin 2025/28 (21) Application number: 23861278.2 (22) Date of filing: 31.08.2023

(51) International Patent Classification (IPC):  A61K 35/17(2025.01) A61P 31/00(2006.01) A61P 37/00(2006.01) C12N 5/10(2006.01) C12N 15/113(2010.01) C12N 9/22(2006.01) A61K 35/15(2025.01) A61P 35/00(2006.01) C12N 15/11(2006.01) A61K 48/00(2006.01) C12N 15/63(2006.01) (52) Cooperative Patent Classification (CPC): A61P 35/00; A61P 31/00; A61P 37/00; C12N 2510/00; C12N 2501/515; C12N 5/0646; C07K 14/4738; A61K 40/15; A61K 40/4258; A61K 40/11; A61K 40/31 (86) International application number: PCT/US2023/031654 (87) International publication number: WO 2024/049971 (07.03.2024 Gazette 2024/10)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA Designated Validation States: KH MA MD TN (30) Priority: 02.09.2022 US 202263374447 P (71) Applicant: Baylor College of Medicine Houston, TX 77030 (US)	(72) Inventors: METELITSA, Leonid, S. Houston, TX 77030 (US) HECZEY, Andras Houston, TX 77030 (US) XU, Xin Houston, TX 77030 (US) COURTNEY, Amy, N. Houston, TX 77030 (US) (74) Representative: J A Kemp LLP  80 Turnmill Street London EC1M 5QU London EC1M 5QU (GB)