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(11)

EP 4 580 642 A2

(12)

(88) Date of publication A3: 25.04.2024 (43) Date of publication: 09.07.2025 Bulletin 2025/28 (21) Application number: 23861474.7 (22) Date of filing: 29.08.2023

(51) International Patent Classification (IPC):  A61K 35/17(2025.01) A61P 31/12(2006.01) C07K 14/705(2006.01) C07K 16/28(2006.01) A61P 35/00(2006.01) C07K 16/30(2006.01) C07K 14/725(2006.01) (52) Cooperative Patent Classification (CPC): C12N 2330/51; C12N 15/111; C12N 15/113; C12N 2310/14 (86) International application number: PCT/US2023/073035 (87) International publication number: WO 2024/050325 (07.03.2024 Gazette 2024/10)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA Designated Validation States: KH MA MD TN (30) Priority: 01.09.2022 US 202263403219 P (71) Applicant: SRI International Menlo Park, CA 94025 (US)	(72) Inventors: BHATNAGAR, Parijat Menlo Park, California 94025-3493 (US) RADHAKRISHNAN, Harikrishnan Menlo Park, California 94025-3493 (US) (74) Representative: D Young & Co LLP  3 Noble Street London EC2V 7BQ London EC2V 7BQ (GB)