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EP 4 580 654 A1

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(43) Date of publication: 09.07.2025 Bulletin 2025/28 (21) Application number: 23861046.3 (22) Date of filing: 05.07.2023

(51) International Patent Classification (IPC):  A61K 38/45(2006.01) C07K 7/06(2006.01) C12N 9/48(2006.01) A61K 38/43(2006.01) A61K 47/64(2017.01) C12N 9/64(2006.01) (52) Cooperative Patent Classification (CPC): A61K 47/64; A61K 47/65; A61K 49/0056; A61K 49/0032; A61K 47/6811; C07K 2319/33; C12N 9/1044; C12Y 203/02013; A61K 38/00; C07K 14/415 (86) International application number: PCT/US2023/026914 (87) International publication number: WO 2024/049543 (07.03.2024 Gazette 2024/10)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA Designated Validation States: KH MA MD TN (30) Priority: 30.08.2022 US 202263373947 P 09.12.2022 US 202263431570 P (71) Applicant: THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY Stanford, CA 94305-2038 (US)

(72) Inventors: KHOSLA, Chaitan Stanford, California 94305 (US) LOPPINET, Elise Redwood City, California 94063 (US) BESSER, Harrison Palo Alto, California 94301 (US) (74) Representative: Mewburn Ellis LLP  Aurora Building Counterslip Bristol BS1 6BX Bristol BS1 6BX (GB)