(19)

(11)

EP 4 580 665 A2

(12)

(88) Date of publication A3: 16.05.2024 (43) Date of publication: 09.07.2025 Bulletin 2025/28 (21) Application number: 23861597.5 (22) Date of filing: 01.09.2023

(51) International Patent Classification (IPC):  A61K 39/02(2006.01) C07K 14/20(2006.01) A61P 31/04(2006.01) C07K 16/12(2006.01) (52) Cooperative Patent Classification (CPC): Y02A 50/30; A61K 39/0225; A61P 31/04; C07K 14/20 (86) International application number: PCT/US2023/073311 (87) International publication number: WO 2024/050512 (07.03.2024 Gazette 2024/10)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA Designated Validation States: KH MA MD TN (30) Priority: 02.09.2022 US 202263403451 P 11.05.2023 US 202363501445 P (71) Applicant: The Medical College of Wisconsin, Inc. Milwaukee, WI 53226 (US)	(72) Inventors: LOCHHEAD, Robert B. Germantown, Wisconsin 53022 (US) DANNER, Rebecca L. Milwaukee, Wisconsin 53207 (US) ROUSE, Joseph R. Milwaukee, Wisconsin 53221 (US) PROCHNIAK, Lauren Kenosha, Wisconsin 53142 (US) (74) Representative: J A Kemp LLP  80 Turnmill Street London EC1M 5QU London EC1M 5QU (GB)