(19)

(11)

EP 4 580 670 A2

(12)

(88) Date of publication A3: 23.05.2024 (43) Date of publication: 09.07.2025 Bulletin 2025/28 (21) Application number: 23861577.7 (22) Date of filing: 31.08.2023

(51) International Patent Classification (IPC):  A61K 39/12(2006.01) C07K 14/005(2006.01) C07K 14/155(2006.01) A61K 39/21(2006.01) C07K 14/08(2006.01) (52) Cooperative Patent Classification (CPC): C07K 16/1063; C07K 2317/33; C07K 2317/92; C07K 2317/76; C07K 2299/00; C07K 2317/565; C07K 2317/34; A61K 39/12; C12N 2740/16034; C12N 2740/16134; A61K 2039/55555; A61K 2039/575; C07K 14/005; C12N 2740/16122 (86) International application number: PCT/US2023/073257 (87) International publication number: WO 2024/050488 (07.03.2024 Gazette 2024/10)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA Designated Validation States: KH MA MD TN (30) Priority: 31.08.2022 US 202263402877 P (71) Applicants: Duke University Durham, NC 27705 (US) Triad National Security, LLC Los Alamos, NM 87545 (US)	(72) Inventors: HENDERSON, Rory Durham, NC 27705 (US) ACHARYA, Priyamvada Durham, NC 27705 (US) STALLS, Victoria Durham, NC 27705 (US) HAYNES, Barton, F. Durham, NC 27705 (US) WAGH, Kshitij, G. Los Alamos, NM 87545 (US) KORBER, Bette, T. Los Alamos, NM 87545 (US) (74) Representative: Barker Brettell LLP  100 Hagley Road Edgbaston Birmingham B16 8QQ Birmingham B16 8QQ (GB)