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EP 4 580 673 A2

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(88) Date of publication A3: 25.04.2024 (43) Date of publication: 09.07.2025 Bulletin 2025/28 (21) Application number: 23861547.0 (22) Date of filing: 30.08.2023

(51) International Patent Classification (IPC):  A61K 39/39(2006.01) C07K 16/32(2006.01) C07K 16/28(2006.01) A61P 35/00(2006.01) (52) Cooperative Patent Classification (CPC): C07K 2317/24; C07K 16/2863; C07K 2317/31; C07K 2317/34; C07K 2317/35; C07K 2317/55; C07K 2317/64; C07K 2317/732; C07K 2317/92; C07K 2317/622; A61K 2039/505 (86) International application number: PCT/US2023/073194 (87) International publication number: WO 2024/050439 (07.03.2024 Gazette 2024/10)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA Designated Validation States: KH MA MD TN (30) Priority: 31.08.2022 US 202263402945 P (71) Applicant: SystImmune, Inc. Redmond WA 98052 (US)	(72) Inventors: HELGESON, Luke A. Sammamish, Washington 98075 (US) ROZANITIS, Tyler C. Redmond, Washington 98052 (US) GOULET, Dennis R. Redmond, Washington 98052 (US) KHALILI, Jahan Kirkland, Washington 98034 (US) DAVIS, Nicholas S. Seatle, Washington 98104 (US) ZHU, Yi Chengdu, Sichuan (CN) (74) Representative: Mathys & Squire  The Shard 32 London Bridge Street London SE1 9SG London SE1 9SG (GB)