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EP 4 580 685 A2

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(88) Date of publication A3: 11.04.2024 (43) Date of publication: 09.07.2025 Bulletin 2025/28 (21) Application number: 23861314.5 (22) Date of filing: 31.08.2023

(51) International Patent Classification (IPC):  A61K 48/00(2006.01) A61M 5/168(2006.01) A61P 1/18(2006.01) A61B 5/0215(2006.01) A61M 5/142(2006.01) A61P 1/16(2006.01) A61B 5/03(2006.01) (52) Cooperative Patent Classification (CPC): A61K 31/711 (86) International application number: PCT/US2023/031751 (87) International publication number: WO 2024/050039 (07.03.2024 Gazette 2024/10)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA Designated Validation States: KH MA MD TN (30) Priority: 31.08.2022 US 202263374058 P 31.08.2022 US 202263374070 P 31.08.2022 US 202263374073 P 31.08.2022 US 202263374216 P 31.08.2022 US 202263374228 P 31.08.2022 US 202263374231 P 31.08.2022 US 202263374234 P (71) Applicant: HydroGene Therapeutics, Inc. Houston, Texas 77024 (US)

(72) Inventor: KRUSE, Robert Houston, TX 77024 (US) (74) Representative: Maschio & Soames IP Ltd  30 Carlton Crescent Southampton SO15 2EW Southampton SO15 2EW (GB)