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EP 4 580 749 A1

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(43) Date of publication: 09.07.2025 Bulletin 2025/28 (21) Application number: 23776521.9 (22) Date of filing: 31.08.2023

(51) International Patent Classification (IPC):  A61P 7/00(2006.01) C07K 16/18(2006.01) C07D 207/28(2006.01) A61P 7/06(2006.01) C07K 16/46(2006.01) (52) Cooperative Patent Classification (CPC): A61P 7/00; A61P 7/06; C07K 2317/31; C07K 16/468; C07K 2317/22; C07K 2317/76; C07K 2319/31; A61K 2039/505; A61K 2039/545; C07K 2317/24; C07K 16/18 (86) International application number: PCT/US2023/031615 (87) International publication number: WO 2024/049951 (07.03.2024 Gazette 2024/10)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA Designated Validation States: KH MA MD TN (30) Priority: 31.08.2022 US 202263374154 P 31.07.2023 US 202363529928 P (71) Applicant: Alexion Pharmaceuticals, Inc. Boston, MA 02210 (US)	(72) Inventors: DAI, Yang Boston, Massachusetts 02210 (US) NAJAFIAN, Nader Boston, Massachusetts 02210 (US) GASTEYGER, Christoph Boston, Massachusetts 02210 (US) SHEN, Tong Boston, Massachusetts 02210 (US) (74) Representative: J A Kemp LLP  80 Turnmill Street London EC1M 5QU London EC1M 5QU (GB)