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EP 4 581 036 A1

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(43) Date of publication: 09.07.2025 Bulletin 2025/28 (21) Application number: 23859254.7 (22) Date of filing: 25.08.2023

(51) International Patent Classification (IPC):  C07D 498/22(2006.01) A61P 35/00(2006.01) A61K 31/4545(2006.01) A61P 37/00(2006.01) (52) Cooperative Patent Classification (CPC): C07D 498/22; A61P 37/00; A61P 35/00; C07D 519/00; A61K 45/06 (86) International application number: PCT/CN2023/114848 (87) International publication number: WO 2024/046221 (07.03.2024 Gazette 2024/10)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA Designated Validation States: KH MA MD TN (30) Priority: 02.09.2022 WO PCT/CN2022/116914 13.07.2023 WO PCT/CN2023/107228 (71) Applicant: DIZAL (JIANGSU) PHARMACEUTICAL CO., LTD. Shanghai 201203 (CN)	(72) Inventors: ZENG, Qingbei Shanghai 201203 (CN) TSUI, Honchung Shanghai 201203 (CN) YANG, Zhenfan Shanghai 201203 (CN) ZHANG, Xiaolin Shanghai 201203 (CN) (74) Representative: Simmons & Simmons LLP (Munich)  Lehel Carré Gewürzmühlstraße 11 80538 Munich 80538 Munich (DE)