(19)

(11)

EP 4 581 125 A1

(12)

(43) Date of publication: 09.07.2025 Bulletin 2025/28 (21) Application number: 23861098.4 (22) Date of filing: 18.08.2023

(51) International Patent Classification (IPC):  C12M 3/08(2006.01) C12N 5/0783(2010.01) A61K 35/17(2025.01) (52) Cooperative Patent Classification (CPC): C12N 5/0068; C12N 2533/90; C12N 2533/52; C12M 25/10 (86) International application number: PCT/US2023/030560 (87) International publication number: WO 2024/049658 (07.03.2024 Gazette 2024/10)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA Designated Validation States: KH MA MD TN (30) Priority: 02.09.2022 US 202263403592 P 16.08.2023 US 202318234470 (71) Applicant: Terumo BCT, Inc. Lakewood, CO 80215 (US)	(72) Inventors: JONES, Mark E. Lakewood, Colorado 80215 (US) FRANK, Nathan D. Lakewood, Colorado 80215 (US) MILLER, Mindy M. Lakewood, Colorado 80215 (US) CUNNINGHAM, Ann Marie W. Lakewood, Colorado 80215 (US) SETHI, Dalip Lakewood, Colorado 80215 (US) (74) Representative: J A Kemp LLP  80 Turnmill Street London EC1M 5QU London EC1M 5QU (GB)