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(11)

EP 4 581 129 A1

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(43) Date of publication: 09.07.2025 Bulletin 2025/28 (21) Application number: 23764621.1 (22) Date of filing: 31.08.2023

(51) International Patent Classification (IPC):  C12N 5/073(2010.01) C12N 5/074(2010.01) C12N 5/0735(2010.01) G01N 33/50(2006.01) (52) Cooperative Patent Classification (CPC): C12N 5/0662; C12N 2506/45; C12N 2501/16; C12N 2501/065; C12N 2501/727; C12N 2533/54; C12N 2502/1323; C12N 2501/415; C12N 2501/235; C12N 2501/604; C12N 2500/02; C12N 2501/33 (86) International application number: PCT/EP2023/073949 (87) International publication number: WO 2024/047188 (07.03.2024 Gazette 2024/10)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA Designated Validation States: KH MA MD TN (30) Priority: 31.08.2022 EP 22193280 (71) Applicant: Katholieke Universiteit Leuven 3000 Leuven (BE)	(72) Inventors: PASQUE, Vincent 3010 Kessel-Lo (BE) PHAM, Thi Xuan Ai 3000 Leuven (BE) PANDA, Amitesh 3001 Heverlee (BE) BALATON, Bradley 3000 Leuven (BE) (74) Representative: Arnold & Siedsma  Bezuidenhoutseweg 57 2594 AC The Hague 2594 AC The Hague (NL)