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(11)

EP 4 581 136 A2

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(88) Date of publication A3: 23.05.2024 (43) Date of publication: 09.07.2025 Bulletin 2025/28 (21) Application number: 23861486.1 (22) Date of filing: 29.08.2023

(51) International Patent Classification (IPC):  C12N 9/22(2006.01) C12N 5/07(2010.01) C07K 14/81(2006.01) A61P 7/06(2006.01) A61K 48/00(2006.01) C12N 15/10(2006.01) C12N 5/10(2006.01) A61P 43/00(2006.01) A61K 35/17(2025.01) C12N 5/074(2010.01) (52) Cooperative Patent Classification (CPC): C12N 15/102; C12N 2310/20; C12N 15/907 (86) International application number: PCT/US2023/073068 (87) International publication number: WO 2024/050349 (07.03.2024 Gazette 2024/10)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA Designated Validation States: KH MA MD TN (30) Priority: 30.08.2022 US 202263373990 P 30.12.2022 US 202263477888 P (71) Applicant: Emendobio Inc. Wilmington, DE 19805 (US)	(72) Inventors: EMMANUEL, Rafi 7236710 Ramla (IL) GOLAN MASHIACH, Michal 7405900 Ness Ziona (IL) (74) Representative: Schiweck Weinzierl Koch Patentanwälte Partnerschaft mbB  Ganghoferstraße 68 B 80339 München 80339 München (DE)