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(11)

EP 4 581 173 A2

(12)

(88) Date of publication A3: 23.05.2024 (43) Date of publication: 09.07.2025 Bulletin 2025/28 (21) Application number: 23861574.4 (22) Date of filing: 31.08.2023

(51) International Patent Classification (IPC):  C12Q 1/70(2006.01) G01N 33/569(2006.01) G01N 33/50(2006.01) G01N 33/53(2006.01) (52) Cooperative Patent Classification (CPC): G01N 35/0098; B01L 3/502792; B01L 3/502784; B01L 2400/043; B01L 2300/1827; B01L 7/00; B01L 2300/0816; B01L 2300/0864; G01N 27/745 (86) International application number: PCT/US2023/073249 (87) International publication number: WO 2024/050485 (07.03.2024 Gazette 2024/10)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA Designated Validation States: KH MA MD TN (30) Priority: 02.09.2022 US 202263403656 P (71) Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA Oakland, CA 94607-5200 (US)	(72) Inventors: EMAMINEJAD, Sam Los Angeles, CA 90095-7191 (US) DI CARLO, Dino Los Angeles, CA 90095-7191 (US) LIN, Haisong Los Angeles, CA 90095-7191 (US) YU, Wenzhuo Los Angeles, CA 90095-7191 (US) AMIRMOZAFARISABET, Kiarash Los Angeles, CA 90095-7191 (US) (74) Representative: Ipsilon Benelux  76, rue de Merl 2146 Luxembourg 2146 Luxembourg (LU)