(19)

(11)

EP 4 583 855 A1

(12)

(43) Date of publication: 16.07.2025 Bulletin 2025/29 (21) Application number: 23783649.9 (22) Date of filing: 07.09.2023

(51) International Patent Classification (IPC):  A61K 31/122(2006.01) A61K 31/355(2006.01) A61K 31/52(2006.01) A61K 38/00(2006.01) A61K 41/00(2020.01) A61P 35/00(2006.01) A61K 31/352(2006.01) A61K 31/4745(2006.01) A61K 35/00(2006.01) A61K 39/00(2006.01) A61K 45/06(2006.01) (52) Cooperative Patent Classification (CPC): A61K 45/06; A61P 35/00; A61K 31/122; A61K 31/355; A61K 31/352; A61K 31/4745; A61K 31/52; A61K 38/00; A61N 2005/1098; A61K 38/20; A61K 38/2006; A61K 38/204; A61K 35/17; C07K 16/2896; C07K 2317/75; C07K 16/40; C07K 2317/76; A61K 2039/507   C-Sets: A61K 31/52, A61K 2300/00; A61K 38/20, A61K 2300/00; A61K 38/2006, A61K 2300/00; A61K 38/204, A61K 2300/00; A61K 35/17, A61K 2300/00; A61K 31/122, A61K 2300/00; A61K 31/355, A61K 2300/00; A61K 31/352, A61K 2300/00; A61K 31/4745, A61K 2300/00; (86) International application number: PCT/US2023/073674 (87) International publication number: WO 2024/054934 (14.03.2024 Gazette 2024/11)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA Designated Validation States: KH MA MD TN (30) Priority: 07.09.2022 US 202263404392 P 17.03.2023 US 202363491008 P (71) Applicant: MDX Management LLC La Jolla, CA 92037 (US)	(72) Inventors: LIU, Yuan Decatur, Georgia 30033 (US) SHI, Lei Decatur, Georgia 30032 (US) BIAN, Zhen Tucker, Georgia 30084 (US) STYLLI, Harry La Jolla, California 92037 (US) (74) Representative: CMS Cameron McKenna Nabarro Olswang LLP  Cannon Place 78 Cannon Street London EC4N 6AF London EC4N 6AF (GB)