(19)
(11) EP 4 583 876 A1

(12)

(43) Date of publication:
16.07.2025 Bulletin 2025/29

(21) Application number: 23785938.4

(22) Date of filing: 07.09.2023
(51) International Patent Classification (IPC): 
A61K 31/496(2006.01)
A61P 35/00(2006.01)
A61K 31/519(2006.01)
 A61K 45/06(2006.01)
A61K 31/5025(2006.01)
A61K 39/00(2006.01)
(52) Cooperative Patent Classification (CPC):
A61P 35/00; A61K 45/06; A61K 31/496; A61K 2239/48; A61K 31/519; A61K 40/11; A61K 40/31; A61K 40/32; A61K 40/4211
 
C-Sets:
A61K 40/4211, A61K 2300/00;
(86) International application number:
PCT/US2023/073686
(87) International publication number:
WO 2024/054944 (14.03.2024 Gazette 2024/11)
(84) Designated Contracting States:
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR
Designated Extension States:
BA
Designated Validation States:
KH MA MD TN

(30) Priority: 08.09.2022 US 202263404955 P

(71) Applicant: Juno Therapeutics, Inc.
Seattle, WA 98109 (US)

(72) Inventors:
  • KUGLER, David G.
    Seattle, Washington 98109 (US)
  • QIN, Jim
    Seattle, Washington 98109 (US)
  • MAIER, Alison
    Seattle, Washington 98109 (US)
  • WICHROSKI, Michael
    Princeton, New Jersey 08543 (US)
  • SIVAKUMAR, Pallavur
    Summit, New Jersey 07901 (US)
  • BUSCH, Stephanie
    Seattle, Washington 98109 (US)
  • JONES, Jon
    Seattle, Washington 98109 (US)
  • HILL, Christopher Mark
    Summit, New Jersey 07901 (US)
  • CARLSON, Patrick Andrew
    Seattle, Washington 98109 (US)

(74) Representative: Carpmaels & Ransford LLP 
One Southampton Row
London WC1B 5HA
London WC1B 5HA (GB)

   


(54) COMBINATION OF A T CELL THERAPY AND CONTINUOUS OR INTERMITTENT DGK INHIBITOR DOSING