(19)
(11) EP 4 583 916 A2

(12)

(88) Date of publication A3:
18.04.2024

(43) Date of publication:
16.07.2025 Bulletin 2025/29

(21) Application number: 23863784.7

(22) Date of filing: 07.09.2023
(51) International Patent Classification (IPC): 
A61K 45/06(2006.01)
 A61K 31/15(2006.01)
(52) Cooperative Patent Classification (CPC):
A61P 37/00; A61K 31/10; A61K 31/436; A61K 31/519; A61K 45/06
 
C-Sets:
  1. A61K 31/10, A61K 2300/00;
  2. A61K 31/436, A61K 2300/00;
  3. A61K 31/519, A61K 2300/00;
(86) International application number:
PCT/US2023/032170
(87) International publication number:
WO 2024/054558 (14.03.2024 Gazette 2024/11)
(84) Designated Contracting States:
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR
Designated Extension States:
BA
Designated Validation States:
KH MA MD TN

(30) Priority: 08.09.2022 US 202263374981 P

(71) Applicant: The Children's Hospital Of Philadelphia
Philadelphia, PA 19104 (US)

(72) Inventors:
  • HAKONARSON, Hakon
    Malvern, PA 19355 (US)
  • PANDEY, Rahul
    Wallingford, PA 19086 (US)
  • BAKAY, Marina
    Parkesburg, PA 19365 (US)
  • STRENKOWSKI, Bryan
    Browns Mills, NJ 08015 (US)

(74) Representative: Plougmann Vingtoft a/s 
Strandvejen 70
2900 Hellerup
2900 Hellerup (DK)

   


(54) COMPOSITIONS AND METHODS FOR AMELIORATION OF SYMPTOMS ASSOCIATED WITH CLEC16A DYSFUNCTION OR LOSS