(19)

(11)

EP 4 583 973 A2

(12)

(88) Date of publication A3: 02.08.2024 (43) Date of publication: 16.07.2025 Bulletin 2025/29 (21) Application number: 23908267.0 (22) Date of filing: 18.12.2023

(51) International Patent Classification (IPC):  A61P 19/00(2006.01) A61L 27/36(2006.01) A61K 38/48(2006.01) (52) Cooperative Patent Classification (CPC): C12Y 304/24034; A61K 38/4886; A61P 19/00; A61K 45/06; A61K 9/0085; A61K 9/06; A61K 47/36 (86) International application number: PCT/US2023/084643 (87) International publication number: WO 2024/137513 (27.06.2024 Gazette 2024/26)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA Designated Validation States: KH MA MD TN (30) Priority: 19.12.2022 US 202263433641 P (71) Applicant: The Regents of University of California Oakland, CA 94607-5200 (US)	(72) Inventors: FIELDS, Aaron San Francisco, California 94143 (US) LOTZ, Jeffrey San Francisco, California 94143 (US) SZOKA, Frank San Francisco, California 94143 (US) DOLOR, Aaron San Francisco, California 94143 (US) HABIB, Mohamed San Francisco, California 94143 (US) (74) Representative: Williams Powell  330 High Holborn London WC1V 7QH London WC1V 7QH (GB)