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EP 4 584 366 A1

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(43) Date of publication: 16.07.2025 Bulletin 2025/29 (21) Application number: 23768500.3 (22) Date of filing: 06.09.2023

(51) International Patent Classification (IPC):  C12N 5/074(2010.01) C12N 15/867(2006.01) C07K 14/435(2006.01) C07K 14/47(2006.01) G01N 33/48(2006.01) C07K 14/475(2006.01) (52) Cooperative Patent Classification (CPC): C12N 5/0696; C07K 14/475; C07K 14/47; C12N 5/0606; C12N 2510/00; C12N 15/86; C12N 2740/16043; C12N 2830/003 (86) International application number: PCT/EP2023/074510 (87) International publication number: WO 2024/052434 (14.03.2024 Gazette 2024/11)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA Designated Validation States: KH MA MD TN (30) Priority: 06.09.2022 EP 22194243 15.05.2023 EP 23173488 07.08.2023 EP 23190084 (71) Applicant: Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. 80539 München (DE)

(72) Inventors: VELYCHKO, Sergiy 48149 Münster (DE) SCHÖLER, Hans R. 48149 Münster (DE) MACCARTHY, Caitlin M. 48149 Münster (DE) COJOCARU, Vlad 48149 Münster (DE) WU, Guangming 48149 Münster (DE) (74) Representative: Vossius & Partner Patentanwälte Rechtsanwälte mbB  Siebertstraße 3 81675 München 81675 München (DE)