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(11)

EP 4 584 369 A1

(12)

(43) Date of publication: 16.07.2025 Bulletin 2025/29 (21) Application number: 23863757.3 (22) Date of filing: 06.09.2023

(51) International Patent Classification (IPC):  C12N 5/0783(2010.01) A61P 35/00(2006.01) A61K 35/17(2025.01) (52) Cooperative Patent Classification (CPC): A61P 35/00; A61K 35/17; C12N 5/0638; C12N 2501/2302; C12N 2501/2315; C12N 2501/2321 (86) International application number: PCT/US2023/032111 (87) International publication number: WO 2024/054518 (14.03.2024 Gazette 2024/11)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA Designated Validation States: KH MA MD TN (30) Priority: 07.09.2022 US 202263374891 P 02.05.2023 US 202363499685 P (71) Applicant: Nextvivo, Inc. Palo Alto, California 94304 (US)	(72) Inventors: LEUSHACKE, Marc Palo Alto, California 94304 (US) JU, Jihang Palo Alto, California 94304 (US) HYSENAJ, Lisiena Palo Alto, California 94304 (US) MARGOLIN, Adam Palo Alto, California 94304 (US) CHARTIER-COURTAUD, Cecile Palo Alto, California 94304 (US) (74) Representative: Brand Murray Fuller LLP  50 Eastcastle Street London W1W 8EA London W1W 8EA (GB)