(19)

(11)

EP 4 584 594 A1

(12)

(43) Date of publication: 16.07.2025 Bulletin 2025/29 (21) Application number: 23863683.1 (22) Date of filing: 30.08.2023

(51) International Patent Classification (IPC):  G01N 33/68(2006.01) G01N 30/72(2006.01) H01J 49/00(2006.01) G01N 33/483(2006.01) (52) Cooperative Patent Classification (CPC): G01N 30/72; G01N 33/6848; G01N 2400/10; G01N 2333/315; G01N 30/88; H01J 49/004 (86) International application number: PCT/US2023/031494 (87) International publication number: WO 2024/054382 (14.03.2024 Gazette 2024/11)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA Designated Validation States: KH MA MD TN (30) Priority: 06.09.2022 US 202263403984 P (71) Applicant: Purdue Research Foundation West Lafayette, IN 47906 (US)	(72) Inventors: COOKS, Robert, Graham Lafayette, IN 47906 (US) HOLDEN, Dylan, T. Lafayette, IN 47905 (US) LE, Myphuong, T. Lafayette, IN 47906 (US) MANHEIM, Jeremy Kenilworth, NJ 07033 (US) IYER, Kiran Kenilworth, NJ 07033 (US) (74) Representative: HGF  HGF Limited 1 City Walk Leeds LS11 9DX Leeds LS11 9DX (GB)