(19)
(11) EP 4 638 463 A1

(12)

(43) Date of publication:
29.10.2025 Bulletin 2025/44

(21) Application number: 22854582.8

(22) Date of filing: 23.12.2022
(51) International Patent Classification (IPC): 
C07J 31/00(2006.01)
A61P 1/16(2006.01)
A61P 9/10(2006.01)
 A61K 31/575(2006.01)
A61P 3/06(2006.01)
(52) Cooperative Patent Classification (CPC):
C07J 31/006; C07B 2200/13; A61P 1/16; A61P 3/06; A61P 9/10; A61K 31/575
(86) International application number:
PCT/US2022/053981
(87) International publication number:
WO 2024/136884 (27.06.2024 Gazette 2024/26)
(84) Designated Contracting States:
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR
Designated Extension States:
BA
Designated Validation States:
KH MA MD TN

(71) Applicant: Durect Corporation
Cupertino, CA 95014-4166 (US)

(72) Inventors:
  • MIKSZTAL, Andrew R.
    Palo Alto, California 94306 (US)
  • GONZALEZ, Mario
    Winchester, MA 01890 (US)
  • SARD, Howard
    Arlington, MA 02476 (US)
  • LIN, WeiQi
    Emerald Hills, CA 94062 (US)
  • MORENCY, Cynthia
    Andover, MA 01810 (US)

(74) Representative: J A Kemp LLP 
80 Turnmill Street
London EC1M 5QU
London EC1M 5QU (GB)

   


(54) SALTS INCLUDING CRYSTALLINE SALTS OF 25-HYDROXY-CHOLEST-5-EN-3-SULFATE AND METHODS FOR PREPARING SAME