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EP 4 680 222 A1

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(43) Date of publication: 21.01.2026 Bulletin 2026/04 (21) Application number: 24771680.6 (22) Date of filing: 13.03.2024

(51) International Patent Classification (IPC):  A61K 31/198(2006.01) A23L 33/175(2016.01) A61K 31/22(2006.01) A23L 33/12(2016.01) A61K 31/205(2006.01) (52) Cooperative Patent Classification (CPC): A23L 33/175; A61K 31/198; A61K 45/06 (86) International application number: PCT/US2024/019789 (87) International publication number: WO 2024/192165 (19.09.2024 Gazette 2024/38)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA Designated Validation States: GE KH MA MD TN (30) Priority: 14.03.2023 US 202363452060 P 12.04.2023 US 202363458684 P (71) Applicant: The Board of Trustees of the Leland Stanford Junior University Stanford, CA 94305-2038 (US)

(72) Inventors: LONG, Jonathan Z. Redwood City, California 94063 (US) LI, Veronica L. Redwood City, California 94063 (US) MOYA GARZON, Maria de los Dolores Redwood City, California 94063 (US) BANIK, Steven M. Redwood City, California 94063 (US) (74) Representative: Patentwerk B.V.  P.O. Box 1514 5200 BN 's-Hertogenbosch 5200 BN 's-Hertogenbosch (NL)