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(11)

EP 4 680 230 A1

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(43) Date of publication: 21.01.2026 Bulletin 2026/04 (21) Application number: 24775441.9 (22) Date of filing: 15.03.2024

(51) International Patent Classification (IPC):  A61K 31/395(2006.01) A61K 31/505(2006.01) A61K 31/44(2006.01) A61K 31/33(2006.01) (52) Cooperative Patent Classification (CPC): A61K 31/7076 (86) International application number: PCT/US2024/020148 (87) International publication number: WO 2024/196760 (26.09.2024 Gazette 2024/39)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA Designated Validation States: GE KH MA MD TN (30) Priority: 17.03.2023 US 202363452832 P (71) Applicant: Academia Sinica Taipei 11529 (TW)	(72) Inventors: CHERN, Yijuang Taipei 11529 (TW) HSIEH, Christine, Chin-jung Taipei 11529 (TW) LEE, Yi-Chao Taipei City 115011 (TW) CHEN, You-Yin New Taipei City 244008 (TW) FANG, Jim-Min Taipei City 106216 (TW) (74) Representative: Charrier Rapp & Liebau  Patentanwälte PartG mbB Fuggerstraße 20 86150 Augsburg 86150 Augsburg (DE)