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EP 4 680 243 A1

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(43) Date of publication: 21.01.2026 Bulletin 2026/04 (21) Application number: 24720357.3 (22) Date of filing: 15.03.2024

(51) International Patent Classification (IPC):  A61K 31/513(2006.01) A61K 31/711(2006.01) A61K 31/7088(2006.01) A61P 27/02(2006.01) (52) Cooperative Patent Classification (CPC): A61P 27/02; A61K 31/7088; A61K 31/513; A61K 31/675; A61K 31/683; A61K 31/5377; A61K 31/47; A61K 31/155; A61K 31/635; A61K 31/7105; A61K 45/06; C12N 9/22; C12N 2310/20; C12N 15/1132; C12N 2310/14; A61K 38/1891; A61K 35/761; A61K 35/30   C-Sets: A61K 31/47, A61K 2300/00; A61K 31/155, A61K 2300/00; A61K 31/635, A61K 2300/00; A61K 31/7105, A61K 2300/00; A61K 31/7088, A61K 2300/00; A61K 35/761, A61K 2300/00; A61K 31/675, A61K 2300/00; A61K 38/1891, A61K 2300/00; A61K 31/683, A61K 2300/00; C12N 2310/14, C12N 2310/531; A61K 31/513, A61K 2300/00; A61K 31/5377, A61K 2300/00; (86) International application number: PCT/US2024/020294 (87) International publication number: WO 2024/196814 (26.09.2024 Gazette 2024/39)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA Designated Validation States: GE KH MA MD TN (30) Priority: 17.03.2023 US 202363453006 P (71) Applicant: The United States of America, as represented by the Secretary, Department of Health and Human Services Bethesda, Maryland 20892-7788 (US)

(72) Inventors: BHARTI, Kapil Bethesda, Maryland 20892 (US) ZHANG, Congxiao Bethesda, Maryland 20892 (US) FAUSEY, Andrew Jacob Minster, Ohio 45865 (US) SHARMA, Ruchi Bethesda, Maryland 20892 (US) (74) Representative: Symbiosis IP Limited  Innovation Centre Innovation Way Heslington, York YO10 5DG Heslington, York YO10 5DG (GB)