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EP 4 680 250 A1

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(43) Date of publication: 21.01.2026 Bulletin 2026/04 (21) Application number: 24775476.5 (22) Date of filing: 15.03.2024

(51) International Patent Classification (IPC):  A61K 31/7105(2006.01) A61P 7/00(2006.01) C12N 15/113(2010.01) A61K 9/00(2006.01) C07K 14/755(2006.01) C12Q 1/6883(2018.01) (52) Cooperative Patent Classification (CPC): A61K 31/7105; A61P 7/00; C07K 14/755; C12N 15/113; A61K 9/0019; A61K 9/08; C12N 2310/315; C12N 2310/11; C12N 2320/33; C12N 2310/321   C-Sets: C12N 2310/321, C12N 2310/3525; (86) International application number: PCT/US2024/020275 (87) International publication number: WO 2024/196804 (26.09.2024 Gazette 2024/39)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA Designated Validation States: GE KH MA MD TN (30) Priority: 17.03.2023 US 202363453036 P (71) Applicant: The Regents of the University of California Oakland, CA 94607-5200 (US)	(72) Inventors: SANFORD, Jeremy Santa Cruz, California 95064 (US) STONE, Michael Santa Cruz, California 95064 (US) TSE, Victor Santa Cruz, California 95064 (US) CHACALTANA, Guillermo Santa Cruz, California 95064 (US) (74) Representative: Boult Wade Tennant LLP  Salisbury Square House 8 Salisbury Square London EC4Y 8AP London EC4Y 8AP (GB)