(19)

(11)

EP 4 680 251 A1

(12)

(43) Date of publication: 21.01.2026 Bulletin 2026/04 (21) Application number: 24771646.7 (22) Date of filing: 13.03.2024

(51) International Patent Classification (IPC):  A61K 31/7115(2006.01) A61P 35/00(2006.01) A61K 31/7125(2006.01) C12N 15/113(2010.01) (52) Cooperative Patent Classification (CPC): C12N 15/113; A61P 35/00; C12N 2310/315; C12N 2310/113; C12N 2310/3231; C12N 2310/3181; A61K 45/06 (86) International application number: PCT/US2024/019719 (87) International publication number: WO 2024/192115 (19.09.2024 Gazette 2024/38)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA Designated Validation States: GE KH MA MD TN (30) Priority: 14.03.2023 US 202363490184 P (71) Applicants: Thomas Jefferson University Philadelphia, PA 19107 (US) Bound Therapeutics, LLC Cherry Hill, NJ 08003 (US)	(72) Inventors: WICKSTROM, Eric Philadelphia, PA 19130 (US) JIN, Yuanyuan NY 08003 (US) (74) Representative: Plougmann Vingtoft a/s  Strandvejen 70 2900 Hellerup 2900 Hellerup (DK)