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(11)

EP 4 680 253 A1

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(43) Date of publication: 21.01.2026 Bulletin 2026/04 (21) Application number: 24771683.0 (22) Date of filing: 13.03.2024

(51) International Patent Classification (IPC):  A61K 35/15(2025.01) A61P 37/06(2006.01) A61K 35/12(2015.01) C12N 5/0784(2010.01) (52) Cooperative Patent Classification (CPC): A61K 35/15; A61P 37/06; C12N 5/0639; C12N 2501/125; C12N 2501/145; A61K 2035/122 (86) International application number: PCT/US2024/019799 (87) International publication number: WO 2024/192172 (19.09.2024 Gazette 2024/38)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA Designated Validation States: GE KH MA MD TN (30) Priority: 13.03.2023 US 202363489839 P (71) Applicants: University of Massachusetts Westborough, MA 01581 (US) Loyola University of Chicago Maywood, Illinois 60153 (US) Hasentech, Inc. Leverett, MA 01054 (US)

(72) Inventors: OSBORNE, Barbara Leverett, Massachusetts 01054 (US) KNIGHT, Katherine Chicago, Illinois 60601 (US) MINTER, Lisa M. Amherst, Massachusetts 01002 (US) KALININA, Olga Chicago, Illinois 60612 (US) GOLDSBY, Richard Leverett, Massachusetts 01054 (US) (74) Representative: V.O.  P.O. Box 87930 2508 DH Den Haag 2508 DH Den Haag (NL)