(19)

(11)

EP 4 680 258 A1

(12)

(43) Date of publication: 21.01.2026 Bulletin 2026/04 (21) Application number: 24712584.2 (22) Date of filing: 11.03.2024

(51) International Patent Classification (IPC):  A61K 35/742(2015.01) A61K 47/26(2006.01) A61P 25/18(2006.01) A61K 47/22(2006.01) A61K 47/36(2006.01) A61P 25/28(2006.01) (52) Cooperative Patent Classification (CPC): A61P 25/28; A61P 25/18; A61K 35/742 (86) International application number: PCT/IB2024/052354 (87) International publication number: WO 2024/194737 (26.09.2024 Gazette 2024/39)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA Designated Validation States: GE KH MA MD TN (30) Priority: 17.03.2023 US 202363452948 P 29.03.2023 US 202363455339 P 23.06.2023 US 202363509996 P 23.06.2023 US 202363510000 P 27.10.2023 US 202363593760 P (71) Applicant: Artugen Therapeutics Ltd. Dublin 2 (IE)

(72) Inventors: CHESNEL, Laurent 82140 Sant Antonin Noble Val (FR) ACTON, Susan L. Lexington, Massachusetts 02421 (US) (74) Representative: J A Kemp LLP  80 Turnmill Street London EC1M 5QU London EC1M 5QU (GB)