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EP 4 680 264 A2

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(88) Date of publication A3: 24.10.2024 (43) Date of publication: 21.01.2026 Bulletin 2026/04 (21) Application number: 24771700.2 (22) Date of filing: 14.03.2024

(51) International Patent Classification (IPC):  A61K 38/21(2006.01) C07K 14/56(2006.01) A61P 35/00(2006.01) (52) Cooperative Patent Classification (CPC): C07K 14/555; A61K 45/06; C07K 14/56; A61K 38/212; C07K 16/2818; A61P 35/00; C07K 16/2827; C07K 16/2803; A61K 39/39541; A61K 39/39558; A61K 2039/505; C07K 2319/50   C-Sets: A61K 38/212, A61K 2300/00; A61K 39/39541, A61K 2300/00; A61K 39/39558, A61K 2300/00; (86) International application number: PCT/US2024/019833 (87) International publication number: WO 2024/192195 (19.09.2024 Gazette 2024/38)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA Designated Validation States: GE KH MA MD TN (30) Priority: 14.03.2023 US 202363490240 P 03.04.2023 US 202363493802 P (71) Applicant: Jazz Pharmaceuticals Ireland Limited 4 Dublin (IE)

(72) Inventors: SALMERON-GARCIA, Jose, Andres Watertown, MA 02472 (US) BRODKIN, Heather, R. Watertown, MA 02472 (US) ECONOMIDES, Kyriakos Watertown, MA 02472 (US) HICKLIN, Daniel, J. Watertown, MA 02472 (US) SEIDEL-DUGAN, Cynthia Watertown, MA 02472 (US) STEINER, Philipp, W. Watertown, MA 02472 (US) WINSTON, William, M. Watertown, MA 02472 (US) NIRSCHL, Christopher, J. Watertown, MA 02472 (US) HUMPHREYS, Robin, C. Dublin 4 (IE) (74) Representative: Mathys & Squire  The Shard 32 London Bridge Street London SE1 9SG London SE1 9SG (GB)