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EP 4 680 266 A2

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(88) Date of publication A3: 07.11.2024 (43) Date of publication: 21.01.2026 Bulletin 2026/04 (21) Application number: 24771747.3 (22) Date of filing: 14.03.2024

(51) International Patent Classification (IPC):  A61K 38/46(2006.01) C12N 15/00(2006.01) A61K 48/00(2006.01) A61P 21/00(2006.01) (52) Cooperative Patent Classification (CPC): C12N 15/86; C12N 2750/14143; C12N 2740/16043; C12N 9/22; C12N 15/907; C12N 2310/20; C12N 15/113; A61K 48/005; A61K 48/0075; A61K 31/7105; C07K 14/4705; A61P 35/00; A61K 38/465   C-Sets: A61K 31/711, A61K 2300/00; A61K 31/7105, A61K 2300/00; (86) International application number: PCT/US2024/019974 (87) International publication number: WO 2024/192263 (19.09.2024 Gazette 2024/38)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA Designated Validation States: GE KH MA MD TN (30) Priority: 16.03.2023 US 202363490678 P 17.08.2023 US 202363520253 P 24.10.2023 US 202363592882 P (71) Applicant: Epicrispr Biotechnologies, Inc. South San Francisco, CA 94080 (US)

(72) Inventors: COLLIN DE L'HORTET, Alexandra Sylvie South San Francisco, California 94080 (US) ADHIKARI, Abhinav South San Francisco, California 94080 (US) (74) Representative: Zacco Denmark A/S  Arne Jacobsens Allé 15 2300 Copenhagen S 2300 Copenhagen S (DK)