(19)
(11) EP 4 680 272 A1

(12)

(43) Date of publication:
21.01.2026 Bulletin 2026/04

(21) Application number: 24775534.1

(22) Date of filing: 18.03.2024
(51) International Patent Classification (IPC): 
A61K 39/02(2006.01)
C12P 19/18(2006.01)
 C07K 14/195(2006.01)
(52) Cooperative Patent Classification (CPC):
A61K 2039/6068; A61K 2039/6043; A61K 39/0208; A61K 2039/55566; A61K 2039/575; A61K 2039/545; C12R 2001/01; C12P 21/02; C12P 19/04; C40B 40/02; C40B 40/10; C12N 15/1037
(86) International application number:
PCT/US2024/020423
(87) International publication number:
WO 2024/196880 (26.09.2024 Gazette 2024/39)
(84) Designated Contracting States:
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR
Designated Extension States:
BA
Designated Validation States:
GE KH MA MD TN

(30) Priority: 17.03.2023 US 202363490869 P

(71) Applicants:
  • Cornell University
    Ithaca, New York 14850 (US)
  • Georgia Tech Research Corporation
    Atlanta, GA 30318 (US)

(72) Inventors:
  • DELISA, Matthew
    Ithaca, New York 14850 (US)
  • SINGH, Ankur
    Atlanta, Georgia 30318 (US)
  • MOELLER, Tyler
    Ithaca, New York 14850 (US)
  • SHAH, Shivem
    Ithaca, New York 14850 (US)

(74) Representative: HGF 
HGF Limited 4th Floor, 1 City Square
Leeds LS1 2AL
Leeds LS1 2AL (GB)

   


(54) COMPOSITIONS AND METHODS FOR PREDICTING IMMUNE RESPONSES TO SUBUNIT VACCINES USING SYNTHETIC IMMUNE ORGANOIDS