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EP 4 680 276 A1

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(43) Date of publication: 21.01.2026 Bulletin 2026/04 (21) Application number: 24716066.6 (22) Date of filing: 15.03.2024

(51) International Patent Classification (IPC):  A61K 39/12(2006.01) C12N 15/67(2006.01) C12N 15/69(2006.01) C12N 15/10(2006.01) C12N 15/68(2006.01) (52) Cooperative Patent Classification (CPC): C12N 15/67; C12N 2310/532; C12P 19/34 (86) International application number: PCT/US2024/020317 (87) International publication number: WO 2024/192422 (19.09.2024 Gazette 2024/38)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA Designated Validation States: GE KH MA MD TN (30) Priority: 15.03.2023 US 202363490517 P (71) Applicant: Flagship Pioneering Innovations VI, LLC Cambridge, MA 02142 (US)	(72) Inventors: BRONSTEIN, Revital Cambridge, MA 02142 (US) HOBERT, Elissa, Magdalene Cambridge, MA 02142 (US) KAZAKOV, Teymur, Spartakovich Cambridge, MA 02142 (US) PAEK, Ki, Young Cambridge, MA 02142 (US) (74) Representative: Carpmaels & Ransford LLP  One Southampton Row London WC1B 5HA London WC1B 5HA (GB)