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EP 4 680 343 A1

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(43) Date of publication: 21.01.2026 Bulletin 2026/04 (21) Application number: 24771852.1 (22) Date of filing: 15.03.2024

(51) International Patent Classification (IPC):  A61P 35/00(2006.01) C07D 333/52(2006.01) C07D 309/14(2006.01) C07D 487/10(2006.01) (52) Cooperative Patent Classification (CPC): A61P 35/00; C07D 471/10; C07D 405/12; C07D 211/26; C07D 405/06; C07D 211/58; C07D 333/70; C07D 409/04; C07D 333/38; C07D 409/12 (86) International application number: PCT/US2024/020301 (87) International publication number: WO 2024/192415 (19.09.2024 Gazette 2024/38)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA Designated Validation States: GE KH MA MD TN (30) Priority: 15.03.2023 US 202363452329 P 14.07.2023 US 202363526918 P (71) Applicants: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA Oakland, CA 94607-5200 (US) Eindhoven University Of Technology 5612 AE Eindhoven (NL)

(72) Inventors: ARKIN, Michelle, R. San Francisco, CA 94143 (US) KONSTANTINIDOU, Markella San Francisco, CA 94143 (US) OTTMANN, Christian 5612 AE Eindhoven (NL) BRUNSVELD, Lucas 5612 AE Eindhoven (NL) VISSER, Emira, Josien 5612 AE Eindhoven (NL) SIJBESMA, Eline 5612 AE Eindhoven (NL) RENSLO, Adam, R. San Francisco, CA 94143 (US) JAISHANKAR, Priyadarshini San Francisco, CA 94143 (US) (74) Representative: HGF  HGF Limited 4th Floor, 1 City Square Leeds LS1 2AL Leeds LS1 2AL (GB)