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EP 4 680 595 A2

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(88) Date of publication A3: 07.11.2024 (43) Date of publication: 21.01.2026 Bulletin 2026/04 (21) Application number: 24719912.8 (22) Date of filing: 14.03.2024

(51) International Patent Classification (IPC):  C07D 207/327(2006.01) C07D 405/12(2006.01) A61K 31/00(2006.01) C07D 211/34(2006.01) A61P 43/00(2006.01) (52) Cooperative Patent Classification (CPC): C07D 211/34; C07D 207/327; C07D 405/12; A61P 43/00 (86) International application number: PCT/US2024/019990 (87) International publication number: WO 2024/192277 (19.09.2024 Gazette 2024/38)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA Designated Validation States: GE KH MA MD TN (30) Priority: 15.03.2023 US 202363452292 P 15.03.2023 US 202363452293 P 15.03.2023 US 202363490298 P 15.03.2023 US 202363490305 P 15.03.2023 US 202363490311 P 15.03.2023 US 202363490312 P 15.03.2023 US 202363490381 P 15.03.2023 US 202363490384 P 15.03.2023 US 202363490385 P 15.03.2023 US 202363490387 P 12.02.2024 US 202463552484 P (71) Applicant: Renagade Therapeutics Management Inc. Watertown, MA 02472 (US)

(72) Inventors: JAYARAMAN, Muthusamy Watertown, MA 02472 (US) SANKARAN, Ganapathy Subramanian Watertown, MA 02472 (US) KOSAKOWSKA, Karolina Anna Watertown, MA 02472 (US) (74) Representative: Conn, Anne-Marie et al Kilburn & Strode LLP Lacon House 84 Theobalds Road London WC1X 8NL London WC1X 8NL (GB)