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EP 4 680 619 A1

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(43) Date of publication: 21.01.2026 Bulletin 2026/04 (21) Application number: 24771303.5 (22) Date of filing: 13.03.2024

(51) International Patent Classification (IPC):  C07K 14/015(2006.01) C12N 7/00(2006.01) C12N 15/86(2006.01) A61K 35/76(2015.01) (52) Cooperative Patent Classification (CPC): A61K 35/76; C12N 15/86; C07K 14/005; C12N 2750/14143; C12N 2750/14122; A61K 48/005 (86) International application number: PCT/SG2024/050151 (87) International publication number: WO 2024/191354 (19.09.2024 Gazette 2024/38)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA Designated Validation States: GE KH MA MD TN (30) Priority: 13.03.2023 SG 10202300688R (71) Applicant: Agency for Science, Technology and Research Singapore 138632 (SG)

(72) Inventors: MELIANI, Mohamed Amine Singapore 60 Biopolis Street, Genome 02-01 Singapore 138672 (SG) SEAH, Yu Fen Samantha Singapore 60 Biopolis Street, Genome 02-01 Singapore 138672 (SG) TRACZYK, Anna Singapore 60 Biopolis Street, Genome 02-01 Singapore 138672 (SG) CHEW, Wei Leong Singapore 60 Biopolis Street, Genome 02-01 Singapore 138672 (SG) (74) Representative: Vossius & Partner Patentanwälte Rechtsanwälte mbB  Siebertstraße 3 81675 München 81675 München (DE)