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EP 4 680 625 A1

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(43) Date of publication: 21.01.2026 Bulletin 2026/04 (21) Application number: 24713391.1 (22) Date of filing: 12.03.2024

(51) International Patent Classification (IPC):  C07K 14/47(2006.01) A61K 48/00(2006.01) (52) Cooperative Patent Classification (CPC): C07K 14/47; C12N 15/90; C12N 2740/16043; C12N 15/85; C12N 2750/14143; C12N 2830/008; C12N 2800/22; C12N 2310/20; C12N 2320/12; C12N 15/113; C12N 2310/14; C12N 2330/31; C12N 2320/33; G01N 33/6872; C12N 2501/998; C07K 14/705; C12N 2506/45; C12N 2533/50; C12N 2501/65; C12N 5/0657; C07K 16/18 (86) International application number: PCT/EP2024/056577 (87) International publication number: WO 2024/189038 (19.09.2024 Gazette 2024/38)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA Designated Validation States: GE KH MA MD TN (30) Priority: 15.03.2023 US 202363452252 P (71) Applicants: European Molecular Biology Laboratory 69117 Heidelberg (DE) Max-Delbrück-Centrum für Molekulare Medizin 13125 Berlin (DE) The Board of Trustees of the Leland Stanford Junior University Stanford, CA 94305-2038 (US)

(72) Inventors: STEINMETZ, Lars 69117 Heidelberg (DE) KORNIENKO, Julia 69117 Heidelberg (DE) FENZL, Kai 69117 Heidelberg (DE) RODRÍGUEZ-MARTÍNEZ, Marta 69117 Heidelberg (DE) GOTTHARDT, Michael 13125 Berlin (DE) (74) Representative: Krauss, Jan  SKM-IP PartGmbB Oberanger 45 80331 München 80331 München (DE)