(19)

(11)

EP 4 680 627 A1

(12)

(43) Date of publication: 21.01.2026 Bulletin 2026/04 (21) Application number: 24769609.9 (22) Date of filing: 12.03.2024

(51) International Patent Classification (IPC):  C07K 14/47(2006.01) A61K 39/395(2006.01) C07K 7/06(2006.01) C07K 16/18(2006.01) C07K 19/00(2006.01) C12N 15/12(2006.01) C12N 15/87(2006.01) A61K 39/00(2006.01) A61P 35/00(2006.01) C07K 14/725(2006.01) C07K 16/30(2006.01) C12N 5/10(2006.01) C12N 15/86(2006.01) (52) Cooperative Patent Classification (CPC): A61P 35/00; C12N 15/85; C12N 5/0693; C07K 14/4748; A61K 39/0011; C07K 7/06 (86) International application number: PCT/CA2024/050300 (87) International publication number: WO 2024/187278 (19.09.2024 Gazette 2024/38)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA Designated Validation States: GE KH MA MD TN (30) Priority: 13.03.2023 US 202363489855 P 24.07.2023 US 202363515149 P (71) Applicant: Université de Montréal Montréal, Québec H3T 1J4 (CA)	(72) Inventors: PERREAULT, Claude Montréal, Québec H2V 2X1 (CA) THIBAULT, Pierre Montreal, Québec H2M 2M8 (CA) HARDY, Marie-Pierre Terrebonne, Québec J6Y 0A5 (CA) VINCENT, Krystel Terrebonne, Québec J6W 0B4 (CA) APAVALOAEI, Anca New York, New York 10044 (US) (74) Representative: Mathys & Squire  The Shard 32 London Bridge Street London SE1 9SG London SE1 9SG (GB)