(19)

(11)

EP 4 680 642 A2

(12)

(88) Date of publication A3: 24.10.2024 (43) Date of publication: 21.01.2026 Bulletin 2026/04 (21) Application number: 24771725.9 (22) Date of filing: 14.03.2024

(51) International Patent Classification (IPC):  C07K 16/28(2006.01) A61P 35/00(2006.01) A61K 47/68(2017.01) C12N 9/14(2006.01) (52) Cooperative Patent Classification (CPC): C07K 2319/00; C07K 2319/10; C07K 16/18; C07K 2317/569; C07K 2317/22; C07K 16/44 (86) International application number: PCT/US2024/019923 (87) International publication number: WO 2024/192235 (19.09.2024 Gazette 2024/38)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA Designated Validation States: GE KH MA MD TN (30) Priority: 14.03.2023 US 202363490151 P 27.10.2023 US 202363593669 P (71) Applicant: Ohio State Innovation Foundation Columbus, OH 43210 (US)	(72) Inventors: CHU, Nam Columbus, OH 43210 (US) LE, Nhat Columbus, OH 43210 (US) (74) Representative: Berggren Oy  P.O. Box 16 Fabianinkatu 21 00101 Helsinki 00101 Helsinki (FI)