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(11)

EP 4 680 717 A1

(12)

(43) Date of publication: 21.01.2026 Bulletin 2026/04 (21) Application number: 24769980.4 (22) Date of filing: 14.03.2024

(51) International Patent Classification (IPC):  C12M 3/00(2006.01) C12N 5/071(2010.01) B33Y 80/00(2015.01) C12N 5/09(2010.01) B33Y 10/00(2015.01) (52) Cooperative Patent Classification (CPC): B33Y 80/00; B33Y 10/00; C12N 5/0697; C12N 5/0691; C12N 5/0693; C12M 23/16; C12M 21/08; C12M 25/14 (86) International application number: PCT/CN2024/081585 (87) International publication number: WO 2024/188290 (19.09.2024 Gazette 2024/38)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA Designated Validation States: GE KH MA MD TN (30) Priority: 14.03.2023 US 202363490077 P (71) Applicant: The University of Hong Kong Hong Kong (HK)	(72) Inventors: MAN, Kwan Pokfulam Hong Kong (HK) YEUNG, Wai Ho Oscar Pokfulam Hong Kong (HK) CHENG, Fredrick Yum Hung Pokfulam Hong Kong (HK) ZHU, Jiye Pokfulam Hong Kong (HK) LU, Jian Hong Kong (HK) MAO, Zhengyi Hong Kong (HK) (74) Representative: HGF  HGF Limited 4th Floor, 1 City Square Leeds LS1 2AL Leeds LS1 2AL (GB)