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EP 4 680 727 A2

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(88) Date of publication A3: 21.11.2024 (43) Date of publication: 21.01.2026 Bulletin 2026/04 (21) Application number: 24775387.4 (22) Date of filing: 13.03.2024

(51) International Patent Classification (IPC):  C12N 5/0781(2010.01) C12N 15/86(2006.01) C07K 16/10(2026.01) C12N 15/113(2010.01) C12N 9/22(2006.01) C12N 5/10(2006.01) (52) Cooperative Patent Classification (CPC): C12N 15/86; C12N 2710/10322; C12N 2710/10343; C12N 2710/10345; C12N 2810/859; C07K 14/005; C12N 5/0635; A61K 48/005; C12N 15/907; C07K 16/1045; C07K 2317/569; C07K 16/2878; C07K 16/2803; C07K 16/2887; C12N 2510/00; C12N 5/0636; C12N 2501/2304 (86) International application number: PCT/US2024/019736 (87) International publication number: WO 2024/196669 (26.09.2024 Gazette 2024/39)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA Designated Validation States: GE KH MA MD TN (30) Priority: 17.03.2023 US 202363452960 P 07.04.2023 US 202363495050 P 28.06.2023 US 202363510822 P (71) Applicants: Walking Fish Therapeutics, Inc. South San Francisco, CA 94080 (US) Washington University Saint Louis, MO 63130 (US)

(72) Inventors: SELBY, Mark San Francisco, CA 94131 (US) PARK, Hangil Redwood City, CA 94062 (US) ROMANO, Rosa San Mateo, CA 94401 (US) CURIEL, David, T. St. Louis, MO 63105 (US) BOUCHER, Paul St. Louis, MO 63139 (US) LU, Zhi, Hong Ballwin, MO 63011 (US) (74) Representative: Cameron Intellectual Property Ltd  Moncrieff House 69 West Nile Street Glasgow G1 2QB Glasgow G1 2QB (GB)