(19)

(11)

EP 4 680 729 A1

(12)

(43) Date of publication: 21.01.2026 Bulletin 2026/04 (21) Application number: 24774024.4 (22) Date of filing: 15.03.2024

(51) International Patent Classification (IPC):  C12N 5/0783(2010.01) A61P 35/00(2006.01) A61K 35/17(2025.01) C12N 5/00(2006.01) (52) Cooperative Patent Classification (CPC): A61P 35/00; C12N 5/0636; C07K 14/54; C07K 14/57; C07K 14/545; C07K 14/5443; C07K 14/5406; A61K 40/11; A61K 40/31; A61K 40/4215; C12N 2740/15043; A61K 2239/31; A61K 2239/38; A61K 2239/48 (86) International application number: PCT/CN2024/081892 (87) International publication number: WO 2024/193459 (26.09.2024 Gazette 2024/39)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA Designated Validation States: GE KH MA MD TN (30) Priority: 17.03.2023 WO PCT/CN2023/082247 (71) Applicant: Legend Biotech Ireland Limited Dublin 18, D18 T934 (IE)	(72) Inventors: LIU, Baowei Nanjing, Jiangsu 211100 (CN) ZHANG, Qinghe Nanjing, Jiangsu 211100 (CN) TU, Zhongyuan Nanjing, Jiangsu 211100 (CN) ZHANG, Yafeng Nanjing, Jiangsu 211100 (CN) (74) Representative: Murgitroyd & Company  165-169 Scotland Street Glasgow G5 8PL Glasgow G5 8PL (GB)