(19)
(11) EP 4 680 737 A2

(12)

(88) Date of publication A3:
31.10.2024

(43) Date of publication:
21.01.2026 Bulletin 2026/04

(21) Application number: 24771754.9

(22) Date of filing: 14.03.2024
(51) International Patent Classification (IPC): 
C12N 15/11(2006.01)
C12N 9/22(2006.01)
C12N 15/90(2006.01)
C12N 9/12(2006.01)
(52) Cooperative Patent Classification (CPC):
C12N 2310/20; C12N 15/113; A61K 31/7105; A61K 48/005; A01K 2217/072; A01K 2227/105; A01K 2207/15; A01K 2267/03; A61K 48/0025; A61K 48/0041; C12N 15/90
 
C-Sets:
A61K 31/7105, A61K 2300/00;
(86) International application number:
PCT/US2024/019981
(87) International publication number:
WO 2024/192270 (19.09.2024 Gazette 2024/38)
(84) Designated Contracting States:
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR
Designated Extension States:
BA
Designated Validation States:
GE KH MA MD TN

(30) Priority: 15.03.2023 US 202363490442 P
21.03.2023 US 202363491490 P
17.11.2023 US 202363600472 P

(71) Applicant: Flagship Pioneering Innovations VI, LLC
Cambridge, MA 02142 (US)

(72) Inventors:
  • CHIVATAKARN, Onanong
    Cambridge, Massachusetts 02142 (US)
  • APPONI, Luciano Henrique
    Cambridge, Massachusetts 02142 (US)
  • BOTHMER, Anne Helen
    Cambridge, Massachusetts 02142 (US)
  • MCALLISTER, Gregory David
    Cambridge, Massachusetts 02142 (US)
  • COTTA-RAMUSINO, Cecilia Giovanna Silvia
    Cambridge, Massachusetts 02142 (US)
  • STEINBERG, Barrett Ethan
    Cambridge, Massachusetts 02142 (US)
  • QUERBES, William
    Cambridge, Massachusetts 02142 (US)
  • WANG, Zhan
    Cambridge, Massachusetts 02142 (US)
  • MIR, Aamir
    Cambridge, Massachusetts 02142 (US)
  • NAIR, Rahul Ravindran
    Cambridge, Massachusetts 02142 (US)
  • BRODYAGIN, Nikita
    Cambridge, Massachusetts 02142 (US)
  • BRIONES, John Frederick
    Cambridge, Massachusetts 02142 (US)

(74) Representative: Maiwald GmbH 
Elisenhof Elisenstraße 3
80335 München
80335 München (DE)

   


(54) PAH-MODULATING SYSTEMS AND METHODS