SELECTIVE DELIVERY OF ONCO-SUPPRESSIVE MIRNA (MIR126) TO METASTATIC MELANOMA CELLS RESISTANT TO THERAPIES - Patent 4680739

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EP 4 680 739 A1

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(43)	Date of publication:
	21.01.2026 Bulletin 2026/04

(21)	Application number: 24712594.1

(22)	Date of filing: 14.03.2024

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International Patent Classification (IPC):

C12N 15/113^(2010.01)
A61K 38/00^(2006.01)
A61K 47/00^(2006.01)
B82Y 5/00^(2011.01)

A61K 31/00^(2006.01)
A61K 39/00^(2006.01)
A61P 31/00^(2006.01)

(52)	Cooperative Patent Classification (CPC):
	A61P 31/00; C12N 15/1135; C12N 2310/141; C12N 2310/344; C12N 2320/32; A61K 9/5161; A61K 31/7105; C07K 2317/622

	C-Sets:
	C12N 2310/321, C12N 2310/3521;

(86)	International application number:
	PCT/IB2024/052487

(87)	International publication number:
	WO 2024/189572 (19.09.2024 Gazette 2024/38)

(84)	Designated Contracting States:
	AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR
	Designated Extension States:
	BA
	Designated Validation States:
	GE KH MA MD TN

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Priority:

14.03.2023 IT 202300004770

(71)	Applicants:
	Istituto Superiore di Sanità 00161 Roma (IT) Università degli Studi di Roma "La Sapienza" 00185 Roma (IT)

(72)	Inventors:
	FELLI, Nadia 00161 Roma (IT) FELICETTI, Federica 00161 Roma (IT) BIFFONI, Mauro 00161 Roma (IT) FLEGO, Michela 00161 Roma (IT) ARASI, Maria Beatrice 00161 Roma (IT) PALOCCI, Cleofe 00161 Roma (IT)

(74)	Representative: Croce, Valeria
	Jacobacci & Partners S.p.A. Via Senato, 8 20121 Milano 20121 Milano (IT)

(54)	SELECTIVE DELIVERY OF ONCO-SUPPRESSIVE MIRNA (MIR126) TO METASTATIC MELANOMA CELLS RESISTANT TO THERAPIES