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EP 4 680 745 A2

(12)

(88) Date of publication A3: 07.11.2024 (43) Date of publication: 21.01.2026 Bulletin 2026/04 (21) Application number: 24775437.7 (22) Date of filing: 15.03.2024

(51) International Patent Classification (IPC):  C12N 15/113(2010.01) A61K 31/7088(2006.01) A61K 9/127(2025.01) A61K 31/713(2006.01) A61P 25/28(2006.01) A61K 48/00(2006.01) (52) Cooperative Patent Classification (CPC): A61K 31/711; C12N 15/113; C12N 2310/315; C12N 2310/3515; C12N 2310/14; C12N 2320/11; C12N 2310/343; C12N 2320/32   C-Sets: C12N 2310/321, C12N 2310/3521; C12N 2310/322, C12N 2310/3533; (86) International application number: PCT/US2024/020125 (87) International publication number: WO 2024/196753 (26.09.2024 Gazette 2024/39)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA Designated Validation States: GE KH MA MD TN (30) Priority: 17.03.2023 US 202363490866 P (71) Applicant: Arrowhead Pharmaceuticals, Inc. Pasadena, CA 91105 (US)

(72) Inventors: SUK, Ji Young San Diego, California 92130 (US) ESAU, Christine San Diego, California 92131 (US) LI, Xiaokai San Diego, California 92131 (US) LAZZARA, Phillip MADISON, Wisconsin 53719 (US) PEI, Tao MADISON, Wisconsin 53719 (US) NICHOLAS, Anthony Oregon, Wisconsin 53575 (US) CARLSON, Jeffrey MADISON, Wisconsin 53719 (US) STEIN, Ivar San Diego, California 92131 (US) (74) Representative: Arnold & Siedsma  Bezuidenhoutseweg 57 2594 AC The Hague 2594 AC The Hague (NL)