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EP 4 680 747 A1

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(43) Date of publication: 21.01.2026 Bulletin 2026/04 (21) Application number: 24707225.9 (22) Date of filing: 28.02.2024

(51) International Patent Classification (IPC):  C12N 15/45(2006.01) A61K 39/155(2006.01) C07K 14/135(2006.01) C07K 14/005(2006.01) (52) Cooperative Patent Classification (CPC): C12N 2760/18534; C12N 2760/18522; A61K 39/12; C07K 14/005; A61P 31/14; A61K 2039/53; A61K 2039/55555; A61K 2039/575 (86) International application number: PCT/EP2024/055127 (87) International publication number: WO 2024/193965 (26.09.2024 Gazette 2024/39)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA Designated Validation States: GE KH MA MD TN (30) Priority: 17.03.2023 US 202363452728 P 17.03.2023 US 202363452760 P 17.03.2023 US 202363452793 P 16.06.2023 WO PCT/EP2023/066330 16.06.2023 WO PCT/EP2023/066332 16.06.2023 US 202363521403 P 16.06.2023 US 202363521415 P (71) Applicant: GlaxoSmithKline Biologicals S.A. 1330 Rixensart (BE)

(72) Inventors: BIANCUCCI, Marco Rockville, Maryland 20850 (US) MOUSAVI, Kambiz Rockville, Maryland 20850 (US) BARROWS, Nicholas John Rockville, Maryland 20850 (US) WANG, Xiaofeng Rockville, Maryland 20850 (US) MALLETT, Corey Rockville, Maryland 20850 (US) PHUNG, Emily Rockville, Maryland 20850 (US) (74) Representative: Ternon, Thibault  GSK Legal & Compliance - Global Patents 79 New Oxford Street London WC1A 1DG London WC1A 1DG (GB)