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EP 4 680 751 A1

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(43) Date of publication: 21.01.2026 Bulletin 2026/04 (21) Application number: 24769605.7 (22) Date of filing: 11.03.2024

(51) International Patent Classification (IPC):  C12N 15/85(2006.01) A61K 48/00(2006.01) C12N 7/01(2006.01) C12N 15/55(2006.01) C12N 15/864(2006.01) A61K 38/46(2006.01) A61P 3/06(2006.01) C12N 9/20(2006.01) C12N 15/63(2006.01) (52) Cooperative Patent Classification (CPC): A61P 3/06; C12N 2750/14143; C12N 2830/00; C12N 2830/008; C12N 2830/42; C12N 2830/48; A61K 48/005; A61K 48/0058; A61K 48/0066; A61K 48/0075; C12N 2710/10343; A01K 2217/075; A01K 2227/105; A01K 2267/0362; C12N 2800/22; C12N 2830/50; C12N 15/86; C12N 9/18; C12Y 301/01034 (86) International application number: PCT/CA2024/050295 (87) International publication number: WO 2024/187274 (19.09.2024 Gazette 2024/38)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA Designated Validation States: GE KH MA MD TN (30) Priority: 14.03.2023 US 202363490105 P (71) Applicants: National Research Council of Canada Ottawa, Ontario K1A 0R6 (CA) University Of British Columbia Vancouver, British Columbia V6T 1Z3 (CA)

(72) Inventors: MEHTA, Neel Vancouver, British Columbia V5X 0H5 (CA) CHAHAL, Parminder Laval, Québec H7W 5L9 (CA) COULOMBE, Nathalie Montreal, Québec H9C 2R8 (CA) GILBERT, Rénald Cornwall, Ontario K6H 6M3 (CA) MORENO, Maria Ottawa, Ontario K1C 1H7 (CA) MULLICK, Alaka Cote Saint Luc, Québec H4W 1S9 (CA) ROSS, Colin Burnaby, British Columbia V5B 2H7 (CA) STANIMIROVIC, Danica Ottawa, Ontario K4P 1R7 (CA) HAYDEN, Michael Reuben Vancouver, British Columbia V6R 1W9 (CA) (74) Representative: dompatent  Partnerschaft von Patentanwälten und Rechtsanwälten mbB Deichmannhaus am Dom Bahnhofsvorplatz 1 50667 Köln 50667 Köln (DE)