(19)

(11)

EP 4 681 215 A1

(12)

(43) Date of publication: 21.01.2026 Bulletin 2026/04 (21) Application number: 24771815.8 (22) Date of filing: 15.03.2024

(51) International Patent Classification (IPC):  G16H 20/17(2018.01) A61B 5/145(2006.01) A61M 5/172(2006.01) A61K 38/28(2006.01) (52) Cooperative Patent Classification (CPC): G16H 20/17; G16H 40/67; G16H 40/63; G16H 50/50; G16H 20/60; A61B 5/14532; A61B 5/4839; A61B 5/7275; A61M 2005/14208; A61K 38/00 (86) International application number: PCT/US2024/020182 (87) International publication number: WO 2024/192362 (19.09.2024 Gazette 2024/38)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA Designated Validation States: GE KH MA MD TN (30) Priority: 16.03.2023 US 202363452569 P (71) Applicant: University of Virginia Charlottesville, Virginia 22904-4301 (US)

(72) Inventors: BRETON, Marc D. Charlottesville, Virginia 22901 (US) COLMEGNA, Patricio Charlottesville, Virginia 22901 (US) VILLA TAMAYO, Maria Fernanda Charlottesville, Virginia 22903 (US) GARCIA-TIRADO, Jose Earlysville, Virginia 22936 (US) DIAZ-CASTAÑEDA, Jenny L. Charlottesville, Virginia 22902 (US) MOSCOSO-VASQUEZ, Marcela Charlottesville, Virginia 22901 (US) (74) Representative: Grünecker Patent- und Rechtsanwälte PartG mbB  Leopoldstraße 4 80802 München 80802 München (DE)